McAdams doubts feasibility of the original cast's return in the upcoming musical adaptation.
Fey and Meadows will return as Ms. Norbury and the school's principal in the adaptation.
Rice as Cady, Rapp as Regina, Wood as Gretchen, and Vandanapu as Karen join the new cast.
McAdams compliments Rapp's talent and is excited to see her take on Regina's role.
The actresses consider the possibility of a Mean Girls sequel focused on their original characters.
The movie adaptation is inspired by the Broadway musical that ran from 2017 to 2019.
The original film is based on Rosalind Wiseman's 2002 book, Queen Bees and Wannabes.
The classic teen comedy, released in 2004, became a modern classic and inspired the musical adaptation.
The Mean Girls musical movie adaptation is headed to the streaming platform Paramount+.
McAdams is open to returning if Tina Fey can find a suitable way to include the original cast.